A parastomal hernia is a type of incisional hernia that occurs when abdominal contents, like the intestine, push through the muscle opening created for the stoma.1 It is one of the most frequent long-term complications of stoma surgery, affecting up to 50% of patients, often within the first few years.3 While not always dangerous, a stoma hernia can cause discomfort, interfere with the fit of your ostomy appliance, and impact your quality of life
With regard to distribution , for drugs such as diazepam 1 and penfluridol 5 that are substantially distributed into adipose tissue, greater adiposity is associated with greater storage of the drug in lipid reservoirs, and hence greater availability of the drug for return to blood as blood levels fall due to metabolism
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HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice
Think of them as chromosomal shoelace aglets, protecting the ends from damage
Z., Yang, Y., Whiteman, M., Moore, P